Earlier studies indicated that co-culture with tumors cells could induce the polarization of THP1 or THP1-derived macrophages toward M2 phenotype 30-33. While this iSNAP-MC treatment can inhibit tumor progression of human Blymphoma (Figure 5), varying the dosage and duration of iSNAP-MC may further enhance the therapeutic efficacy. Furthermore, in the present study, a single dose of iSNAP-MC by intra-tumoral injection was used to treat tumor. With Next-Generation Sequencing and proteomics technology, the downstream molecular candidates of iSNAP can be further identified and modulated to improve the therapeutic efficacy of iSNAP-MC. As shown in Figures 3 and 4, iSNAP-MΦ exhibit the phenotype of M1 macrophages, with increased secretion of pro-inflammatory chemokines and cytokines. A knockout of endogenous SIRPα by genetic engineering should hence further improve the efficiency of our approach. The iSnap project has also produced public datasets, consisting of log data from students working in an introductory computing class, which can be found on the PSLC Datashop.C shows that the mRNA expression of endogenous SIRPα was also observed in iSNAP-MΦ although this is much lower than that of the engineered SIRPα, endogenous SIRPα should still have functional activity to result in the partial blockade of the "Don't eat me" signal. Papers and Datasetsįor all iSnap-related papers, see the list at the bottom of this page. ISnap offers a basic interface to navigate and view the logs it generates. Note: this is a demo site and does not include actual student data. Logs can be saved to a database for future analysis, review or grading. ISnap logs all actions taken by students in the environment, as well as snapshots of students’ code as they work. Students can request hints about whole scripts or individual blocks. When a student is stuck, they can request a hint with the click of a button. At the C:Windows prompt, type the following command, and then press ENTER: ren c:windowssystem32driversisapnp.sys isapnp.old. Note If the administrator password is blank, just press ENTER. The assignment asks you to create a guessing game, in which the computer stores a random number and then repeated asks the player to guess it, telling them if they are too high, too low or correct. When you are prompted for the Administrator password, type the password, and then press ENTER. The above demo shows off iSnap’s newest hint interface, but much of the earlier research with iSnap used a simpler hint interface, based on the Contextual Tree Decomposition (CTD) algorithm. If the suggestion is followed, the button or input outline disappears, indicating the student has successfully followed the hint. Blue + buttons and input outlines indicating where new blocks can be insertedĬlicking a button or highlighted input will show a next-step hint, comparing a student’s current code to iSnap’s suggested code.If a student requests a next-step hint, iSnap also adds: Hovering over a yellow-highlighted block will show where it can be moved. Blocks that are highlighted in yellow probably do belong in the solution, but may not be in the right place.Blocks that are highlighted in magenta probably don’t belong in a solution.When a student needs help, they can ask iSnap to check their work. Select any assignment and test out the hints. See an explanation of iSnap’s help features below, or try them out yourself at the iSnap demo. The SourceCheck algorithm matches students’ code to previously observed code from students who successfully completed the assignment and recommends an edit based on how those students progressed. Using data collected from real students working on programming assignments, we are able to generate on-demand, next-step hints for students who get stuck on these assignments. The construction of a Snap program and the corresponding evaluation. The iSnap project has also produced various papers and public datasets, which can be found below. A public mirror of iSnap is available on GitHub, but it may be behind the development branch demoed here until features are ready for release. ISnap is a project out of the HINTS lab in collaboartion with the Game2Learn lab at North Carolina State University, with lead development by Thomas Price. Head past the break for some screenshots, the download link and our thoughts For those who don't know by now, Snapchat (is a service popular on the iPhone and Android that. iSnap augments the environment with intelligent features including logging and data-driven hints. Snap is an online, bock-based programming environment designed by researchers at UC Berkeley to make programming more accessible to novices.
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